Living Donor Organ Transplantation

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Living Donor Organ Transplantation

Living Donor Organ Transplantation

Authors: Rainer Gruessner and Enrico Benedetti

Published: December 2007

eISBN: 9780071593304 0071593306 | ISBN: 9780071455497

Contents

Foreword

Preface

Commentary: The Amsterdam and Vancouver Conferences on Living Organ Donation

Part I: General Aspects of Living Donor Organ Transplantation

Chapter 1 Introduction and Rationale

Chapter 2 Cultural Differences in Living Organ Donation: A Global Perspective

Chapter 3 Ethical and Legal Issues

3.1 The American Perspective

3.2 The Asian Perspective

3.3 The European Perspective

Chapter 4 Donor Counseling and Consent

4.1 Teaching and Testing the Knowledge and Thinking of Living Organ Donors

4.2 Informed Consent

4.3 Donor Advocacy

Chapter 5 Nondirected and Controversial Donors

Chapter 6 Social Issues

Part II: Paid Legal and Illegal Organ Donation

Chapter 7 Current Financial Incentives

7.1 Incentives in Western Countries: The Wisconsin Model

7.2 Incentives in Non-Western Countries: The Iranian Model

Chapter 8 Paid Legal Organ Donation

8.1 Pro: The Clinician's Perspective

8.2 Pro: The Philosopher's Perspective

8.3 Con: The Clinician's Perspective

8.4 Con: The Ethicist's Perspective

Chapter 9 Challenges of Paid Organ Donation for Public Health Care Policy

Chapter 10 Illegal Organ Trade: Global Justice and the Traffic in Human Organs

Chapter 11 The Impact of the Internet on Paid Legal and Illegal Organ Donation

Part III: Organ-Specific Aspects of Living Donor Abdominal Organ Transplantation

Section I: Kidney Transplantation

Chapter 12 Kidney Transplantation: Personal Reflections

Chapter 13 History of Living Donor Kidney Transplantation

Chapter 14 Kidney Transplantation: Geographical Differences

Chapter 15 Kidney Transplantation: The Donor

15.1 Selection and Workup

15.2 The Marginal Donor

15.3 Immunologic Evaluation

15.4 Anesthesiologic Considerations

15.5 Surgical Procedures

15.6 Perioperative Care of the Kidney Donor

15.7 Donor Morbidity and Mortality

15.8 Long-Term Outcome

15.9 Psychological Aspects

Chapter 16 Kidney Transplantation: The Recipient

16.1 Selection and Workup

16.2 Anesthesiologic Considerations

16.3 Surgical Procedures

16.4 Ischemia and Reperfusion Injury

16.5 Perioperative Care

16.6 Posttransplant Complications

16.7 Immunosuppressive Therapy

16.8 Immunobiology

16.9 Recurrence of Disease

16.10 Retransplantation

16.11 Pediatric Issues

16.12 Preemptive Living Transplantation: The Ideal Therapeutic Modality for End-Stage Renal Disease

16.13 Long-Term Outcome

16.14 Immunologic Issues

16.15 Living Donor Kidney Transplantation and Malignancy

16.16 Strategies to Maximize the Donor Pool

Chapter 17 Kidney Transplantation: Cost Analysis

Section II: Pancreas Transplantation

Chapter 18 History of and Rationale for Pancreas Transplantation

18.1 History of Living Donor Pancreas Transplantation

18.2 Rationale for Living Donor Pancreas Transplants

Chapter 19 Pancreas Transplantation: The Donor

19.1 Selection and Workup

19.2 Surgical Procedures and Perioperative Care

19.3 Morbidity, Mortality, and Long-Term Outcome

Chapter 20 Pancreas Transplantation: The Recipient

20.1 Selection and Workup

20.2 Surgical Procedures

20.3 Perioperative Care, Immunosuppressive Therapy, and Posttransplant Complications

20.4 The Identical Twin Transplant Experience: Recurrence of Disease

Chapter 21 Registry Report and Long-Term Outcome

Chapter 22 Islet Autotransplantation after Pancreatectomy: History and Outcomes

Chapter 23 Islet Transplantation Using Living Donors

Section III: Liver Transplantation

Chapter 24 Personal Reflections and History of Living Donor Liver Transplantation

Chapter 25 Regional Variations in The U.S. Living Donor Experience

Chapter 26 Institutional Needs for Living Donor: Liver Transplantation

Chapter 27 Role of Split Liver Transplantation from Deceased Donors: Lessons Learned

Chapter 28 Liver Regeneration

Chapter 29 Living Donor Liver Transplantation: The Donor

29.1 Selection and Workup

29.2 Anesthesiologic Considerations

29.3 Surgical Procedures

29.4 Perioperative Care

29.5 Donor Morbidity and Mortality

29.6 Long-Term Donor Outcomes

29.7 Psychological Aspects

Chapter 30 Liver Transplantation: The Recipient

30.1 Selection and Workup

30.2 Anesthesiologic Considerations

30.3 Surgical Procedures

30.4 Optimized Venous Outflow

30.5 Ischemia and Reperfusion Injury

30.6 Small-for-Size Grafts

30.7 Perioperative Care of the Liver Recipient

30.8 Posttransplant Complications

30.9 Interventional Therapies

30.10 Immunosuppressive Therapy

30.11 Immunobiology

30.12 Controversial Indications

30.13 Domino Liver Transplantation

30.14 Liver Retransplantation

30.15 Long-Term Outcome

30.16 Strategies to Maximize the Donor Pool

Chapter 31 Liver Transplantation: Cost Analysis

Section IV: Intestinal Transplantation

Chapter 32 History of Living Donor Intestinal Transplantation

Chapter 33 Intestinal Transplantation – The Donor

33.1 Selection and Workup

33.2 Surgical Procedures and Perioperative Care

33.3 Morbidity, Mortality, Long-Term Outcome

Chapter 34 Intestinal Transplantation – The Recipient

34.1 Selection and Workup

34.2 Surgical Procedures and Perioperative Care

34.3 Immunosuppressive Therapy and Postoperative Complications

34.4 Pathology of Small Bowel Transplantation

34.5 Registry Report and Long-Term Outcome

34.6 Intestinal Transplantion: Cost Analysis

Part IV: Future Developments and Alternatives to Living Donor Transplantation

Chapter 35 Dual-Organ Donation

Chapter 36 Use of Living Donors for HIV-Positive Transplant Candidates

Chapter 37 New Immunosuppressive Protocols

Chapter 38 Strategies to Induce Tolerance

Chapter 39 Xenotransplantation

Chapter 40 Gene Therapy

Chapter 41 Organogenesis and Cloning

Index