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CITATION

van Meurs, Willem. Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology. US: McGraw-Hill Professional, 2011.

Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology

Authors: Willem van Meurs

Published:  July 2011

eISBN: 9780071714464 0071714464 | ISBN: 9780071714457
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  • Contents
  • Foreword
  • Preface
  • Acknowledgments
  • 1 Introduction
  • 1.1 Signals and Systems
  • 1.2 System Properties
  • SISO and MIMO
  • Continuous-Time and Discrete-Time
  • Static and Dynamic
  • Linear and Nonlinear
  • Time-Invariant and Time-Variant
  • 1.3 Modeling and Simulation
  • 1.4 Applications in Biomedical Engineering
  • 1.5 Symbolic Notation
  • Review Problems
  • References and Further Reading
  • Part I Theory
  • 2 Model Requirements
  • 2.1 Qualitative Aspects
  • 2.2 Quantitative Aspects
  • 2.3 Implementation and Interfacing
  • Model Code Implementation
  • Interfacing
  • General Program Requirements
  • 2.4 Target Response Data
  • Review Problems
  • References and Further Reading
  • 3 Conceptual Models
  • 3.1 Block Diagrams
  • 3.2 Component Diagrams
  • 3.3 General Observations on Conceptual Models
  • Review Problems
  • References and Further Reading
  • 4 Mathematical Models
  • 4.1 A Model of Two Physical Systems
  • 4.2 State Variable Models
  • 4.3 Units and Numerical Values
  • 4.4 Direct Representation of Fluid Circuits
  • 4.5 Direct Representation of Gas Uptake and Distribution
  • 4.6 Direct Representation of Simple Transfers in the Nervous System
  • 4.7 Electrical Analogs and State Variable Models of Circuits
  • 4.8 General Observations on Mathematical Models and Parameter Estimation
  • Review Problems
  • References and Further Reading
  • 5 Software Implementation
  • 5.1 Discretization of the Continuous-Time State Equation
  • 5.2 Basic Algorithms for Implementation of the Discrete-Time State Variable Model
  • 5.3 Model Code Verification
  • 5.4 Connecting State Variable Models
  • Review Problems
  • References and Further Reading
  • 6 Simulation Results and Model Validation
  • 6.1 Definitions and Overall Procedure
  • 6.2 Quantitative and Qualitative Methods for Establishing Accuracy
  • 6.3 Range of Validity, Target Data, and Experimental Conditions
  • Review Problems
  • References and Further Reading
  • Part II Applications
  • 7 A Model of the Cardiorespiratory System
  • 7.1 Model Requirements
  • 7.2 Conceptual Model
  • Reference and Further Reading
  • 8 Circulation
  • 8.1 Model Requirements
  • 8.2 Conceptual Models
  • 8.3 Mathematical Models
  • References and Further Reading
  • 9 Respiration
  • 9.1 Model Requirements
  • 9.2 Multiple Models
  • 9.3 Conceptual Models
  • 9.4 Mathematical Models
  • References and Further Reading
  • 10 Physiologic Control
  • 10.1 Model Requirements
  • 10.2 Conceptual Models
  • 10.3 Mathematical Models
  • References and Further Reading
  • Part III Advanced Topics
  • 11 Sensitivity Analysis
  • 11.1 Method
  • 11.2 Application to a Hemodynamic Model
  • References and Further Reading
  • 12 Design of Model-Driven Acute Care Training Simulators
  • 12.1 Training Program Design
  • 12.2 Simulator Design
  • 12.3 Model Requirements
  • References and Further Reading
  • Index